Medication Washout of Psychiatric Drugs for Select Patients May Provide Benefits, Reduce Risks for Patients and Physicians — (Market Wired)

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Market Wired

Sept. 13, 2011

Current Use of Polypharmacy Can Increase Risk Factors, Lead to Toxic Results; Journal Article Accepted for Publication by Neuropsychiatric Disease and Treatment

ALISO VIEJO, CA, Sep 13, 2011 (MARKETWIRE via COMTEX) — CNS Response, Inc. today announced that, according to a new journal article, washing psychiatric medications out of select patients may be beneficial to patients and physicians. In addition, medication washout may also reduce the risks associated with today’s more common practice of polypharmacy, in which physicians prescribe additional psychiatric medications on top of previous medications already being used for a patient.

The paper includes a comparison of the advantages and risks from using medication washout versus polypharmacy with treatment-resistant patients. The findings are reported in a paper entitled, “Polypharmacy Or Medication Washout: An Old Tool Revisited.” The paper has been accepted for publication by “Neuropsychiatric Disease and Treatment,” the journal of the International Neuropsychiatric Association (INA) ( ).

“Polypharmacy is a critical issue for psychiatry, including for primary care physicians who prescribe most of the mental health medications,” said CNS Response’s Chief Medical Officer Daniel Hoffman, M.D., a lead author. “Too many patients are on too many drugs, some of which can have harmful side effects. When done appropriately with the right patients and the right medications, washing medications out of select patients can be valuable in supporting better patient diagnosis and assessing medication needs, and can reduce the risks resulting from unknown drug interactions. While some patients will still need more than one medication as part of their treatment regimen, the ultimate goal is to determine which medications are necessary and effective for individual patients.”

The journal article highlights previous study findings and current data related to medication washout and polypharmacy, including:

                 --  A recently reported study, Combining Medication to Enhance Depression Outcomes(CO-MED), funded by the National Institutes of Health,             started patients on several antidepressants (with synergistic             pharmacological effects) at the same time. The study findings suggest             that for a significant number of patients with major depression,             polypharmacy adds to the side effect burden without an increase in             efficacy.                           --  A recent study of 659 depressed patients found that their rate of             cardiovascular problems increased from 8.8 percent to 30.7 percent             after only six weeks of polypharmacy.                           --  According to an Army report released in 2010, between 2006 and 2009,             101 soldiers died accidentally while taking a toxic combination of             prescription drugs.                           --  Use of polypharmacy in the elderly can lead to morbidity and             mortality. As early as 1992, it was reported that psychotropic agents             are the most commonly misused drugs in the elderly and are associated             with increased illness severity, hospitalizations, number of physician             visits, as well as other issues.                           --  In a study of 2,009 treatment-resistant patients who underwent total             medication washout, only five patients (0.25 percent) discontinued the             washout process due to either rebounding of their original mood             disorder or discontinuation symptoms, while an additional 15 (0.75             percent) complained of an adverse response but continued the washout.             Most of the adverse events were related to mild or moderate             discontinuation symptoms with no mortality or serious morbidity in the             patients' functioning.

The full paper is expected to appear within weeks through the journal’s online site. Once published, the paper may be downloaded at no cost. About CNS Response CNS Response provides reference data and analytic tools for clinicians and researchers in psychiatry. While treatment for mental disorders has doubled in the last 20 years, it is estimated that 17 million Americans have failed two or more medication therapies for their mental disorder. The company recently launched the Psychiatric EEG Evaluation Registry, or PEER Online(TM), a new registry and reporting platform that allows medical professionals to exchange treatment outcome data for patients referenced to objective neurophysiology data obtained through an EEG. PEER Online builds on the company’s original physician-developed database, Referenced-EEG(R) (rEEG(R)). Avoiding trial and error pharmacotherapy, the dominant approach for psychiatric treatment, is the objective of PEER Online(TM).

To read more about the benefits of this patented technology for patients, physicians and payers, please visit . Medical professionals interested in learning more can contact CNS Response at

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995 Except for the historical information contained herein, the matters discussed are forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, as amended. These forward-looking statements involve risks and uncertainties as set forth in the Company’s filings with the Securities and Exchange Commission. These risks and uncertainties could cause actual results to differ materially from any forward-looking statements made herein.

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