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New York Times
AUG. 3, 2015
Richard A. Friedman
[Note: This kind of misleading information, almost certainly directly or indirectly pharma-sponsored , is the reason that the general public remains unaware of the enormous risks – especially relative to the benefits – of SSRIs and other antidepressants. Professor Friedman’s stats on suicide are wrong – we have no idea what the true trends are, because suicide stats have never been reliable. As for the “studies” that note correlations between decreased antidepressant use and youth suicide, they are so badly flawed as to be meaningless. They are conducted by people like R.D. Gibbons who have a vested interest in promoting the myth that these medications are harmless and safe. And you, the reader, probably know it is a myth or you would not be visiting this site. – Ed]
Is our culture of relentless achievement and success driving our young people to suicide? You would certainly think so, given the prevailing narrative in the media about the recent spate of suicides on college campuses: one high-achieving student after another succumbing to the toxic social pressure for perfection.
It’s a plausible but incomplete explanation. No doubt the intense social pressure on young people, especially girls and young women, is daunting, but stress is only part of the story: We should also focus on adolescent mental illness and its treatment.
At least 90 percent of people who commit suicide have a diagnosable and potentially treatable mental illness like depression, or alcohol or other drug abuse problems, often in combination. Suicide is the third leading cause of death among young people and has been rising since 2007. The unidentified killer in this story is untreated psychiatric illness.
In 2013, for example, 8.7 percent of people between the ages of 18 and 25 experienced a major depression episode in the previous year, but only half of them received any psychiatric treatment, according to the National Survey on Drug Use and Health. And in 57 percent of these episodes, patients were seen by a general practitioner or family doctor — neither of whom is typically an expert in the treatment of mental illness.
Worse, antidepressants, which can be lifesaving, are probably being underused in young people. Their use fell significantly after the Food and Drug Administration issued its so-called black-box warning in 2004, stating that all antidepressants were associated with a risk of increased suicidal feeling, thinking and behavior in adolescents. That warning was later extended to young adults.
One very large study, including 1.1 million adolescents and 1.4 million young adults, examined data for automated health care claims for 2000 to 2010 from 11 health plans in the United States Mental Health Research Network. Disturbingly, the study found that antidepressant use plunged 31 percent among adolescents and 24 percent among young adults within two years after the F.D.A. advisory was issued.
It’s not hard to understand why. The F.D.A.’s well-intended warning was alarming to the public and most likely discouraged many patients from taking antidepressants. Physicians, too, were anxious about the admittedly small possible risks posed by antidepressants and were probably more reluctant to prescribe them.
What the public and some in the medical community did not understand then — and perhaps still don’t know — is that the risk of antidepressant treatment is minuscule: In the F.D.A. meta-analysis of some 372 clinical trials involving nearly 100,000 subjects, the rate of suicidal thinking and behavior was 4 percent in people taking antidepressants, compared with 2 percent in people taking a placebo.
This very small risk of suicidal behavior posed by antidepressant treatment has always been dwarfed by the deadly risk of untreated depression: 2 to 15 percent of depressed people actually commit suicide.
The somewhat good news is that the downward trend in antidepressant use among adolescents following the F.D.A. advisory reversed a bit after 2008. Still, the rates of antidepressant use since the F.D.A. warning was issued have remained below the levels that would have been predicted based on pre-warning use patterns.
This pattern is very disturbing, since in the decade before this downturn in prescribing of antidepressants — 1990 to 2000 — there was a steady decline in adolescent suicide rates that coincided with an increase in the use of antidepressants in this age group.
One study found that a 1 percent increase in adolescent use of antidepressants was associated with a decrease of 0.23 suicides per 100,000 adolescents per year. (Of course, correlation cannot prove causality; other factors, like reduced rates of alcohol and drug use and more stringent gun safety regulations during this period, may have played a role, too.)
Since there is no evidence that the F.D.A. black-box warning has been helpful, and there is a very reasonable possibility that it has discouraged patients from taking antidepressants and physicians from prescribing these medications, the government should rescind the black-box warning on antidepressants altogether.
Parents and teenagers, and their doctors, too, should not be afraid of antidepressants and should know that they can be very helpful. Indeed, with careful use and monitoring, they can be lifesaving. The only thing we should all fear is depression, a natural killer that we can effectively treat.
Richard A. Friedman is a professor of clinical psychiatry at Weill Cornell Medical College and a contributing opinion writer.